INTRO
2024
THE
LABS
Aging is the ultimate disease and it’s treatable.
THE KEY TO
LONGEVITY
longevity
/lɒnˈdʒɛvɪti/
long duration of life, length of life
Humanity’s greatest threat is aging
94%
of people pass away due to age related illnesses
50bn
240+
With age we lose the capacity to replace dead cells or repair demaged DNA
cells die in the body everyday
DNA breakages per day
80%
decline in stem cell diversity after the age of 70 year
Hallmarks of aging
Genomic instability
Epigenetic Alterations
Telomere Attrition
Loss of proteostasisy
DNA Level
Diseases
- Cancer
- Alzheimer’s
- Parkinson’s
Deregulated nutrient sensing
Mitochondrial dysfunction
Cellular senescence
Altered Intercellular Communication
Cell Level
- Sarcopenia
- Arthritis
- Diabetes
- Osteoporosis
- Atherosclerosis
Stem Cell Exhaustion
Chronic Inflammation
Gut Dysbiosis
Extracellular matrix dysfunction
Organ Level
- COPD
- Heart disease
- Chronic kidney disease
- Liver cirrhosis
- Stroke
Stem cells are the body’s solution to combat aging.
The progress that will change our lives
3.700+
active cell and gene based clinical trials taking place worldwide
$600bn
expected longevity market value by 2025
21%
longevity market’s annual growth rate
$26bn
expected stem cell market value by 2026
A multi-billion dollar industry is currently growing in labs.
Innovative stem cell therapies and treatments could change the face of medicine.
BILL GATES
- 20+ years of research
- 10+ years of clinic operations
- $25m in investment
- 60,000+ procedures performed
- 12,000+ patients treated
- Unmatched variety of medical conditions treated
- Crutial treatment protocols based on unique track record
The KEY’s vision was realized by the pioneers at Stemaid
Stemaid’s global expansion is The KEY
2004
2007
2010
2012
2024
Formation of stem cell lab
Clinical
trials
begin
Commencement of stem cell distribution
Commencement production of skin-cell derived embryonic stem-cells
Global
expansion
PLURIPOTENT
STEM CELLS
Can differentiate into nearly any cell type in the body
There are two types of stem cells
Traditional Product Portfolios:
MULTIPOTENT
Can differentiate into a limited range of cell types within a specific tissue or organ.
The KEY Product Portfolio:
PLURIPOTENT
Remarkable ability to transform into almost any cell type within the human body, offering unparalleled potential for regenerative medicine and therapeutic applications.
Why use Pluripotent
stem cells?
- 6-10 times more potent than adult or umbilical-cord stem cells in helping the body to heal.
- Safe and effective.
- Accelerates healing in the body within 30 minutes of injection.
- Anti-tumor ‘cancer vaccine’ effect not found in adult or umbilical-cord stem cells.
- Lengthen the telomeres of our DNA.
- Contain the Nanog gene, known for its anti-aging benefits.
- Express Micro RNAs that aid in reversing keloids and scarring.
Stem cell treatment is truly a next-level health innovation that can reverse the wear and tear we put on our bodies and prevent debilitating disease and injury from escalating further.
tony robbins
PLURISOMES
Plurisomes are Pluripotent Exosomes. Exosomes are secretory vesicles released by stem cells. These vesicles play a pivotal role in intercellular communication by transferring their cargo of proteins, lipids, nucleic acids, and other bioactive molecules to recipient cells.
These incredible cells release reparative secretome in response to tissue or medium conditions.
In a clean laboratory setting, Plurisomes are cultured in an ideal in-vitro medium that is completely free from the inflammatory and toxic milieu present in vivo.
What are the benefits of Plurisomes ?
Highly < Specific Messaging Content
Plurisomes contain a wide range of growth factors, peptides, messenger RNA, and micro-RNA that are vital for multi-tissue renewal and repair.
These specific messaging contents play a crucial role in signaling restoration and rejuvenation at any juncture of tissue biology.
Comprehensive Tissue Repair
Pluripotent stem cells and their secreted exosomes have the remarkable ability to repair and restore all 220+ tissue types in the human body.
Their reach is truly comprehensive, making them a powerful tool for whole organism rejuvenation.
Multi-Tissue Biodistribution
Clinical evidence has shown that Plurisomes have a multi-tissue comprehensive biodistribution.
This means that upon application, the therapeutic message of Plurisomes travels to all tissues of the body, ensuring that no area is left untouched.
- Pluripotent Factors: Includes KEY reprogramming factors like Klf4, Oct4, Sox2, cMyc.
- Molecular Diversity: Contains over 60,000 different molecules, including essential microRNAs and mRNAs.
- Comprehensive Effects: Effective in tissue regeneration, immune modulation, and neuroprotection.
vs
Source
Regenerative Potential
Protein and RNA Content
Efficacy in Regeneration
Exosomes
Derived from various cell types
Limited by the source cell type
Typically targeted for specific tissues or conditions
Moderate, dependent on source
Plurisomes
Derived exclusively from pluripotent stem cells
High, due to pluripotent origin allowing differentiation into any cell type
Enriched with pluripotency factors, enhancing regenerative capacity
Broad applicability across multiple tissues and conditions due to pluripotent properties
Superior, with enhanced regenerative capabilities and potential to address complex conditions
Therapeutic Application Range
Varies widely; may not include pluripotent-specific factors
Exosome therapy is the next big thing in skincare - It's all about rejuvenation and getting that youthful glow back.
KIM KARDASHIAN
Pluripotent products address all hallmarks of aging
Genomic Instability
Plurisomes express DNA repair factors
Telomere Attrition
Epigenetic Alteration
Pluripotent genes specialise in edigenetic reprograming
Disabled Macroautophagy
Autophagic machinery activated
Mitochondrial Dysfunction
Cellular Senescence
Evidence of Telomereelongation after treatment
Pluripotent Stem Cell share their young and healthy mitochondria
Plurisomes express senolytic, known to rejuvenate senescent stem cells
Deregulated Nutrient Sensing
Chronic Inflamation
Stem Cell Exhaustion
Altered Intercellular Communication
Restore the balance of nutrient-sensing pathways, such as insulin and IGF-1 signaling
Balance immune response and has anti-inflammatory effect
Plurisomes rejuvenate senescent stem cells
Mirnas from Plurisomes contribute to restore communication
Gut Dysbiosis
Loss of Proteostasis
Replenishes damaged or misfolded proteins and restoring proper protein function
Promote the growth of beneficial bacteria while suppressing harmful ones
Product range
PLURISOMES
Targeted Injections or
via IV
Pluripotent Stem Cells
Generic & Autologous
via IV
PEptides
Epithalon, Thymosin Alpha, Cerebrolysin, BPC-157, Chelation, B-17, GHK-Cu
Product Pipeline
KLOTHO
Skin Care Products
FOLLISTATIN
KEY Deliverables
Look better.
Skin and hair have the potential for rejuvenation by leveraging the power of our own cells to fight the effects of aging.
Enhance vitality and maintain physical performance by utilizing cutting-edge treatments that support muscle strength and joint health.
Stay active.
Age healthier.
The effects of aging accelerate as we get old, leading to disease and frailty. Regenerative cell treatments could help replenish what we lose with age and bring us back to a healthier state.
Join a global network of industry pioneers backed by world renowned science.
Supply Chain
KEY Clinics
KEY Holding LCC
are the treatment centers operated by franchisees under the sub brand „KEY“
holds the know-how and research pool in advanced stem cell therapeutics and makes them accessible to clinic & upscale wellness operators around the globe
KEY Labs
KEY Cells
R&D and production of The KEY Cells product line.
Fully equipped, GMP compliant laboratories.
are the pluripotent products that are cultivated in the labratories and shipped to the franchisees.
KEY Terms
Franchisor
Franchisee
Production and daily delivery of finished products to Franchisees clinic
Has or will acquire licence to operate a medical clinic/practice
- Straightforward fee structure: $500k initiation fee for exclusivity, know-how transfer and marketing material
- Exclusivity will last for 3 years and will be extended by 3 years if the clinic has met its KPIs
- Exclusivity period incepts on the day of treating the first patient
- Minimum order quantity of 900 procedures per annum (ca. 300 patients per annum)
- 20% franchise fee on gross revenue
Has or will recruit qualified practitioners (MD, Nurse)
Laboratory set-up and licensing (c GMP)
Administration of therapies based on strict treatment protocols
Regulatory approval of products/therapies
Ongoing consultation on treatment protocols
Marketing & customer acquisition
Training and education of Franchisees personnel
Exclusivity, referrals, brand usage to be agreed
Comprehensive branding and marketing support
Client referrals
Profitability Scenario
Base Case Scenario | Reference Scenario (Cabo Clinic) | Break even Scenario | |
Number of procedures a day | 10 | 30 | 0.7 |
Days of operation | 300 | 300 | 300 |
Price per procedure | $3k | $3k | $3k |
Gross revenue | $9m | $27m | $630k |
Franchise fee | $1.8m | $5.4m | $130k |
Net revenue | $7.2m | $21.6m | $500k |
COGS ($550 per procedure) | $1.65m | $5m | $500k |
Gross profit | $5.55m | $16.6m | 0 |
Revenue
Franchise Fee
COGS
Marketing
KEY Clinic Reference Scenario
Assumptions:
- days of operation p.a.: 300
- avg. no. of treatments days per patient: 12 stem cells, 4 Plurisomes
- avg. anciallary spend per patient: 10% of total treatment cost
- avg. cost of treatment: Stem cells $2.5k, Plurisomes $3.5k
- avg. revenue per patient: $48.4k
- franchise fee: 15% of revenue
- marketing spend: 10% of revenue
- personnel: 1 MD + 1 nurse per 15 per patients per day
30 procedures per day
$500k
Opex
Net Profit
THE
LABS
Franchisee Requirements
Treatment Facility
- 1 Medical Doctor onsite for consultation and targeted injections
- 1 qualified person for facial treatments (micro needling / facial injections)
- 1-3 Nurses for IV administration
- Cool storage for IV bags and Plurisomes vials
- 40-50sqm treatment area for IV
- Treatment room for facials
Laboratory
Franchisor Infrastucture
- Clean Room ISO 7
- Incubators and/or Bioreactors
- Microscopes
- Equipment for analysis of the stem cells and plurisome composition
- Cryostorage equipment
The KEY is not about feeling and looking younger - it is about being younger
THANK YOU
2024
THE
LABS
DISCLAIMER
This company presentation (“Presentation”) has been prepared by KEY Holding LLC and its affiliates (together, the “KEY”) solely for information purposes and should not be considered an advertisement or offer to sell or solicitation to buy any securities in any jurisdiction. This Presentation does not constitute legal, business, tax or professional advice. The KEY provides this Presentation on a strictly confidential basis solely to the recipient to whom it was delivered by the KEY. The acceptance of this Presentation constitutes an agreement on the part of the recipient hereof and the recipient’s representatives to maintain the confidentiality of the information contained herein. No part of this Presentation may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, without the prior written permission of the KEY. If you received this Presentation without the KEY’s express consent, disregard the entirety of this Presentation, and please destroy all record of it and advise the KEY immediately of its unauthorized distribution. The delivery of this Presentation does not include any representation that there has been no change in the affairs of the KEY since the date this Presentation was prepared.